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KMID : 0613820190290020181
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Journal of Life Science
2019 Volume.29 No. 2 p.181 ~ p.190
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Systemic Analysis of Antibacterial and Pharmacological Functions of Anisi Stellati Fructus
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Han Jeong-A
Choo Ji-Eun
Shon Jee-Won
Kim Youn-Sook
Suh Su-Yeon
An Won-Gun
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Abstract
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The purpose of this study was to acquire the active compounds of Anisi stellati fructus (ASF) and to analyze the genes and diseases it targets, focusing on its antibacterial effects using a system pharmacological analysis approach. Active compounds of ASF were obtained through the Traditional Chinese Medicine Systems Pharmacology (TCMSP) Database and Analysis Platform. This contains the pharmacokinetic properties of active compounds and related drug?target?disease networks, which is a breakthrough in silico approach possible at the network level. Gene information of targets was gathered from the UnitProt Database, and gene ontology analysis was performed using the David 6.8 Gene Functional Classification Tool. A total of 201 target genes were collected, which corresponded to the nine screened active compounds, and 47 genes were found to act on biological processes related to antimicrobial activity. The representative active compounds involved in antibacterial action were luteolin, kaempferol, and quercetin. Among their targets, Chemokine ligand2, Interleukin- 10, Interleukin-6, and Tumor Necrosis Factor were associated with more than three antimicrobial biological processes. This study has provided accurate evidence while saving time and effort to select future laboratory research materials. The data obtained has provided important data for infection prevention and treatment strategies.
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KEYWORD
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Anisi Stellati Fructus, antibacterial action, gene ontology analysis, system pharmacological analysis
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